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Transforming Growth Factor-Beta1 and Myeloid-Derived Suppressor Cells Interplay in Cancer

Author: Juan F. Santibanez

Abstract

Background:

Transforming growth factor-beta1 (TGF-β1) is a pleiotropic cytokine with a double role in cancer through its capacity to inhibit early stages of tumors while enhancing tumor progression at late stages of tumor progression. Moreover, TGF-β1 is a potent immunosuppressive cytokine within the tumor microenvironment that allows cancer cells to escape from immune surveillance, which largely contributes to the tumor progression.

Method:

It has been established that the cancer progression is commonly associated with increased number of Myeloid-derived suppressor cells (MDSC) that are a hallmark of cancer and a key mechanism of immune evasion.

Result:

MDSC represent a population of heterogeneous myeloid cells comprised of macrophages, granulocytes and dendritic cells at immature stages of development. MDSC promote tumor progression by regulating immune responses as well as tumor angiogenesis and cancer metastasis.

Conclusion:

In this review, we present an overview of the main key functions of both TGF-β1 and MDSC in cancer and in the immune system. Furthermore, the mutual contribution between TGF-β1 and MDSC in the regulation of immune system and cancer development will be analyzed.

To access this article, please visit:

https://benthamopen.com/FULLTEXT/TOCIJ-6-1

Lung Cancer Awareness Month!

Lung cancer accounts for about 27 percent of all cancer deaths and is by far the leading cause of cancer death among both men and women. Each year, number of people who died because of lung cancer is increasing than of colon, breast, and prostate cancers combined.

white ribbon brings awareness to lung cancer. Support a friend or family member touched by cancer with lung cancer awareness shirts, ribbons, bracelets, jewelry, tattoos, gifts, and much more! Get bulk pricing on some of our most popular lung cancer awareness products – great for benefits and fundraisers!

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World Arthritis Day 2018!

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World Arthritis Day 2018 is observed on October 12. This day is exclusively meant to raise awareness about arthritis, a condition which affects millions of people across the world. Arthritis is an inflammatory condition which causes pain and stiffness in joints which can worsen with age. The condition is such that it can affect day-to-day functioning of people. On World Arthritis Day, the idea is to raise awareness about arthritis and how it affects lives of people who suffer from it.

World Arthritis Day 2018!

World-Arthritis-Day-bentham-open-banner-1

World Arthritis Day 2018 is observed on October 12. This day is exclusively meant to raise awareness about arthritis, a condition which affects millions of people across the world. Arthritis is an inflammatory condition which causes pain and stiffness in joints which can worsen with age. The condition is such that it can affect day-to-day functioning of people. On World Arthritis Day, the idea is to raise awareness about arthritis and how it affects lives of people who suffer from it.

Maternal Risk Factors Associated with Low Birth Weight in Indonesia

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TOPHJ-11-384_F1
Map indicating the various districts of Azad Jammu and Kashmir region of Pakistan – the study area

To access this article, please visit:

https://benthamopen.com/ABSTRACT/TOPHJ-11-384

World Obesity Day 2018!

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For World Obesity Day 2018, raising awareness about the prevalence, severity and diversity of weight stigma. Stigma occurs in a wide variety of settings and the media has been identified as one of the main perpetrators. Current media portrayals of obesity reinforce inaccurate and negative stereotypes about weight which can lead to weight stigma.

World Obesity Day 2018!

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World Obesity Day is observed globally on 11 October with the view of promoting practical solutions to end the global obesity crisis. It is organised by the World Obesity Federation, a non-profit body which is in official relations with the World Health Organisation and is a collaborating body on the Lancet Commission on Obesity. World Obesity states that its aim is to “lead and drive global efforts to reduce, prevent and treat obesity.”

 

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