Bentham Open

Opening Access to Science

Happy Birthday Dr. Atta Ur Rehman!

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Dr. Atta-ur-Rahman

Co-Executive Editor: The Open Conference Proceedings Journal

Honorary Life Fellow
Kings College
University of Cambridge


Effects of Aerobic Exercise on Anxiety Symptoms and Cortical Activity in Patients with Panic Disorder: A Pilot Study

Author: Eduardo Lattari

Journal:Clinical Practice & Epidemiology in Mental Health



The effects of the aerobic exercise on anxiety symptoms in patients with Panic Disorder (PD) remain unclear. Thus, the investigation of possible changes in EEG frontal asymmetry could contribute to understand the relationship among exercise, brain and anxiety.


To investigate the acute effects of aerobic exercise on the symptoms of anxiety and the chronic effects of aerobic exercise on severity and symptoms related to PD, besides the changes in EEG frontal asymmetry.


Ten PD patients were divided into two groups, Exercise Group (EG; n=5) and Control Group (CG; n=5), in a randomized allocation. At baseline and post-intervention, they submitted the psychological evaluation through Panic Disorder Severity Scale (PDSS), Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), EEG frontal asymmetry, and maximal oxygen consumption (VO2max). On the second visit, the patients of EG being submitted to the aerobic exercise (treadmill, 25 minutes, and 50-55% of heart rate reserve) and the CG remained seated for the same period of time. Both groups submitted a psychological evaluation with Subjective Units of Distress Scale (SUDS) at baseline, immediately after (Post-0), and after 10 minutes of the rest pause (Post-10). The patients performed 12 sessions of aerobic exercise with 48-72 hours of interval between sessions.


In EG, SUDS increased immediately after exercise practice and showed chronic decrease in BAI and BDI-II as well as increased in VO2max (Post-intervention).


Aerobic exercise can promote increase in anxiety acutely and regular aerobic exercise promotes reduction in anxiety levels.

Schematic representation of the experimental procedures.

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Design of FRET Probes for SNP RS1006737, Related to Mood Disorder

Author: Germano Orrù

Journal: Clinical Practice & Epidemiology in Mental Health


Schematic representation of FRET probe structure and the possible melting peak array with rs1006737 alleles.


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World Alzheimer’s Day


2 out of every 3 people globally believe there is little or no understanding of dementia in their countries.The impact of World Alzheimer’s Month is growing, but the stigmatisation and misinformation that surrounds dementia remains a global problem, that requires global action.

World Alzheimer’s Day


World Alzheimer’s Month is the international campaign every September to raise awareness and challenge the stigma that surrounds dementia. September 2018 will mark the 7th World Alzheimer’s Month.

2 out of every 3 people globally believe there is little or no understanding of dementia in their countries.The impact of World Alzheimer’s Month is growing, but the stigmatisation and misinformation that surrounds dementia remains a global problem, that requires global action.

Inter-Pathogen Peptide Sharing and the Original Antigenic Sin: Solving a Paradox

Author: Darja Kanduc

Journal: The Open Immunology Journal



To analyse the peptide commonality among viral, bacterial, and protozoan pathogens, and the immunopathologic consequences in the human host.


HPV16, HCMV, C. diphtheriae, B. pertussis, C. tetani, T. gondii, and T. cruzi were analysed for common amino acid sequences that are additionally shared with the human host. The pentapeptide, a minimal immune determinant in humoral and cellular immune recognition, was used as a measurement unit of the peptide similarity level. Molecular modeling was applied to compare the amino acid contexts containing common minimal determinants.


Twenty-nine pentapeptides were found to occur, even hundreds of times, throughout the analyzed pathogen proteomes as well as in the human proteome. Such vast peptide commonalities together with molecular modeling data support the possibility that a pre-existing immune response to a first pathogen can be boosted by a successive exposure to a second different pathogen, i.e., the primary response to a pathogen can be transformed into a secondary response to a previously encountered different pathogen. Two possible consequences emerge. Firstly, no responses might be elicited against the pathogen lastly encountered either by infection or active immunization, but reactions could occur only with the early sensitizing pathogen, which is no more present in the organism. Secondly, the immune response boosted by the pathogen lastly encountered will find a way out by cross-reacting with human proteins.


This study might explain the “original antigenic sin” phenomenon described seven decades ago [Francis T. Jr. Ann Intern Med 1953;39:203], thus providing explanations for vaccine failures and offering possible clues for designing successful vaccines.

Context-dependent conformations of decapentapeptides containing DLLIR


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Teleburn: Designing A Telemedicine Application to Improve Burn Treatment

Author: Farhang Hosseini

Journal: The Open Medical Informatics Journal


Teleburn’s features for GPs and nurses

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Livelihood Vulnerability Associated with Forest Fire in Pauri-Garhwal, Western Himalaya

Author: Shashidhar Kumar Jha

Journal: The Open Ecology Journal


Digital elevation model of Pauri district

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Adaptation of Newcastle Disease Virus (NDV) in Feral Birds and their Potential Role in Interspecies Transmission

Author: Aziz-ul- Rahman

Journal: The Open Virology Journal


NDV from wild bird origin isolated in different regions/countries, also showed the geographical evolutionary relationship among these countries where it is endemic. For example, NDV from Pakistan, Iran, China and India grouped in same cluster.

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